Volume: 1.1.3
Investigation of the effects of Sugammadex and Rocuronium on rat lung tissue
Zumrut DOGAN1, Ebru ANNAC2, Seda CETİN1, Oznur ULUDAG3
1Adiyaman University Faculty of Medicine, Department of Anatomy, Adiyaman, Türkiye
2Adiyaman University Faculty of Medicine, Department of Histology and Embryology, Adiyaman, Türkiye
3Adiyaman University Faculty of Medicine, Department of Anesthesiology and Reanimation, Adiyaman, Türkiye
Abstract
In this study, sugammadex of used to reverse rocuronium used for surgical operations aimed to be examined effects on the lungs that expel anesthetic agents from the body. The possible mechanism of oxidative damage and the effects of sugammadex on lung morphology are still not understood. Four groups were formed from 32 adult Sprague-Dawley male rats as pure control, control group, sugammadex, and sugammadex-rocuronium. After drug administration, lung tissues were assessed histopathologically and biochemically for oxidative damage. A statistically significant difference was observed between the groups regarding glutathione (GSH) levels in the rat lung. It was observed that rocuronium increased the malondialdehyde (MDA) value, which is considered an indicator of free radical damage in tissues. The sugammadex-rocuronium complex can cause oxidative stress in lung tissue. In group sugammadex, dense fibrosis and lymphoid tissue were found in the connective tissue, while group sugammadex-rocuronium had little fibrosis and lymphoid tissue. In group sugammadex-rocuronium, thickening of the alveolar wall was detected. The effect of sugammadex application on lung tissues has been demonstrated by biochemical and histopathologic data. Rocuronium caused an increase in mast cells in lung tissue. Sugammadex suppressed this increase caused by rocuronium and caused a decrease in mast cells in the lung tissue. Although these data were obtained as a result of experimental studies, we think that they will make a significant contribution to the anesthesia and reanimation patient treatment protocols in the clinic. However, new studies are necessary to determine the toxic effects of sugammadex and sugammadex-rocuronium complex.
Keywords: Sugammadex; rocuronium; lung morphology; oxidative stres; rat
Page; 14-20 PDF