{"id":568,"date":"2024-12-22T19:50:27","date_gmt":"2024-12-22T16:50:27","guid":{"rendered":"https:\/\/ncmrjournal.com.tr\/?p=568"},"modified":"2024-12-22T20:09:03","modified_gmt":"2024-12-22T17:09:03","slug":"volume-1-3-1","status":"publish","type":"post","link":"https:\/\/ncmrjournal.com.tr\/index.php\/2024\/12\/22\/volume-1-3-1\/","title":{"rendered":"Volume: 1.3.1"},"content":{"rendered":"
The effect Eremurus spectabilis<\/em> M. Bieb. on diethylnitrosamine-induced neurotoxicity in hippocampus (cornu ammonis) of rat<\/strong><\/h5>\n

 <\/p>\n

\u00d6mer Faruk Kele\u015f1*<\/sup>, Abdulbaki Demir2<\/sup>, Hac\u0131 Ahmet \u00c7i\u00e7ek1<\/sup>, Kenan Y\u0131ld\u0131zhan3<\/sup>, \u0130smail \u00c7elik4 <\/sup><\/strong><\/p>\n

1<\/sup>Department of Pathology, Faculty of Veterinary Medicine, Van Yuzuncu Yil University, 65080, Van, T\u00fcrkiye<\/p>\n

2<\/sup>Mu\u015f Alparslan University, Bulan\u0131k Vocational High School, 49500, Mu\u015f, T\u00fcrkiye<\/p>\n

3<\/sup>Department of Biophysics, Faculty of Medicine, Van Yuzuncu Yil University, 65080, Van, T\u00fcrkiye<\/p>\n

4<\/sup>Department of Molecular Biology and Genetics, Faculty of Science, Van Yuzuncu Yil University, 65080, Van, T\u00fcrkiye<\/p>\n

 <\/p>\n

Abstract<\/strong><\/p>\n

This study aimed to histopathologically investigate the protective effect of Eremurus spectabilis <\/em>M. Bieb’s on Cornu Ammonis (CA) in diethylnitrosamine (DEN)-induced neurotoxicity.\u00a0 In the study, rats were equally divided into (n=8); Control Group: Rats in this group were not exposed to any treatment, DEN Group: Rats in this group were treated with 150 mg DEN\/kg body weight dissolved in 0.9% physiological water once a month and thioacetamide (TAA) 200 mg \/kg body weight once a week intraperitoneally (i.p.), Lyophilized plant extract (LPE) Group: The rats in this group were given 150 mg DEN\/kg once a month dissolved in 0.9% physiological water, 200 mg TAA\/kg once a week and 100 mg\/kg body weight LPE daily by oral gavage method and fed with standard rat chow and tap water, Nanoparticle plant extract (NPE) Group: Rats in this group were given 150 mg DEN\/kg once a month and TAA 200 mg\/kg once a week (i.p.) and 100 mg\/kg body weight nanoparticle plant extract dissolved in 0.9% physiological water and fed with standard rat chow and tap water by oral gavage method. In our findings, a\u00a0significant reduction in granular layer cells and significant dissociations in CA regions were observed in DEN group rats. There was a slight alleviation in the lesions in the groups to which we gave lyophilized plant extract. In rats treated with nanoparticle plant extract, CA gave an appearance very close to the control group.<\/p>\n

In conclusion, Eremurus spectabilis<\/em> M. Bieb. may exhibit a protective effect against neurotoxicity as well as Alzheimer\u2019s disease and Parkinson\u2019s disease, which are closely associated with the CA regions. Also, it was reported as an important finding that the nanoparticle extract of E. spectabilis<\/em> was more effective than the lyophilized extract.<\/p>\n

Keywords:<\/strong> Diethylnitrosamine, Neurotoxicity, Eremurus spectabilis, <\/em>Cornu Ammonis, Rat.<\/span><\/p>\n

Page; 35-39\u00a0 \u00a0<\/em><\/strong>\u00a0 <\/span>PDF<\/strong><\/a><\/p>\n

DOI: https:\/\/doi.org\/110.5281\/zenodo.14543899<\/a><\/em><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

The effect Eremurus spectabilis M. Bieb. on diethylnitrosamine-induced neurotoxicity in hippocampus (cornu ammonis) of rat   \u00d6mer Faruk Kele\u015f1*, Abdulbaki Demir2, Hac\u0131 Ahmet \u00c7i\u00e7ek1, Kenan Y\u0131ld\u0131zhan3, \u0130smail \u00c7elik4 1Department of Pathology, Faculty of Veterinary Medicine, Van Yuzuncu Yil University, 65080, Van, T\u00fcrkiye 2Mu\u015f Alparslan University, Read More …<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-568","post","type-post","status-publish","format-standard","hentry","category-genel"],"_links":{"self":[{"href":"https:\/\/ncmrjournal.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/568","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ncmrjournal.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ncmrjournal.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ncmrjournal.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ncmrjournal.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=568"}],"version-history":[{"count":5,"href":"https:\/\/ncmrjournal.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/568\/revisions"}],"predecessor-version":[{"id":575,"href":"https:\/\/ncmrjournal.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/568\/revisions\/575"}],"wp:attachment":[{"href":"https:\/\/ncmrjournal.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=568"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ncmrjournal.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=568"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ncmrjournal.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=568"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}